A biocatalytic redox isomerisation.
نویسندگان
چکیده
A bi-enzymatic cascade for the redox-isomerisation of allylic alcohol is presented. Coupling of an alcohol dehydrogenase to an enoate reductase has been successfully applied in one pot for the isomerisation of an allylic alcohol to the corresponding ketone. Critical parameters for yield and selectivity have been investigated.
منابع مشابه
N-Heterocyclic carbene catalysed redox isomerisation of esters to functionalised benzaldehydes† †Electronic supplementary information (ESI) available: Experimental procedures and 1H and 13C NMR of new materials. See DOI: 10.1039/c4sc03726j Click here for additional data file.
N-Heterocyclic carbene catalysed redox isomerisation with reduction about the carbonyl has been developed in the transformation of trienyl esters to tetrasubstituted benzaldehydes. The reaction proceeds in good to excellent yield, and in cases that provide 2,20-biaryls, enantioselectivity is observed. Mechanistic studies demonstrate the intermediacy of a cyclohexenyl b-lactone, while implicatin...
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 53 شماره
صفحات -
تاریخ انتشار 2012